Case Study of Cystic Fibrosis

In today’s lesson, we used a case study about cystic fibrosis as the mechanism to:

  • review the stop codon;
  • connect the concepts of protein structure and function;
  • review how R groups differentiate amino acids;
  • review how R group interactions result in protein folding;
  • discuss “structure equals function”;
  • bring a human face to a genetic disease;
  • and help students recall the mechanism of genetic inheritance.

For the entry task, students were challenged to consider how genes begin and end.  We discussed how mRNA sequences always begin with AUG (which codes for methionine, and amino acid which may also occur elsewhere in a protein).  Students were then reminded of the three “stop codons” and we reviewed how those work to release a protein from the ribosome.  We reviewed the structure of amino acids, focusing on the 20 different R groups and how those R groups each have different properties.  The interactions between R groups determine protein shape, and shape determines protein function.  When the sequence changes, the shape changes, thus changing the function of a protein.  We then moved into the cystic fibrosis case study, first watching the video below and then working through the lesson PowerPoint.

Class concluded with a few additional notes, pictured below:

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