Central Dogma: Chromosome Project

Update: March 2

Today marks the final day of class time for working on this portion of the Chromosome Project.  After our entry task, students who have completed the project will be offered the opportunity to present their work to the class for feedback.  For those who finish early, please complete The New Genetics reading assignment (Chapter 1) from February 9.  When that assignment is complete, the next reading assignment is Chapter 4 from Inside the Cell (define vocabulary words in bold and answer the questions at the end of the chapter).  Notes from the entry task are shown below:

Update: March 1

A complete presentation will have the following sections:

  1. Information connecting Chromosome, DNA, Gene, Protein, and Trait (Disease/Condition)
  2. Information about Disease/Condition
  3. Researcher = Your Name
  4. Research connection between Gene and Disease/Condition
  5. How is the disease/condition inherited? Are the genetics known?
  6. Update references in APA format

Use the Citation Machine website to help you cite your sources using APA format.  Sources need to be referenced on the last slide of the Google Slides document you are working on.

Original Post: February 25

Welcome to the Chromosome Project!  Yesterday you had the opportunity to research one or more genes known to be involved in a genetic disease or condition of interest to you.  You then located the gene on a particular chromosome.

Now your work begins!  Your mission today is to learn as much as you can about the gene you identified yesterday.  Record your findings in the Daily Log located in Google Classroom.

To research your gene, visit the NCBI Human Genome Resources page and enter your gene name into the “Find a Gene” box on the left panel.  Be sure to select “homo sapiens” in the pull-down box.  When the search completes, click on your gene name (typically the first gene on the list) and browse through the entry.  There is a ton of information provided!  The length of the gene can be found by hovering your mouse over the top green line under the “genomic regions, transcripts, and products” and looking for the number after the word “length.”  The length of the amino acid sequence can be found by clicking on the word “protein” on the right hand side of the page under Related Information.  Browse the entries for the full-length protein and note the number of amino acids in the protein.  The full-length protein can be challenging to find: look for an entry that does not include words like truncatedisoformpredicted, synthetic construct, or unnamed protein product.

Another great website to visit to learn more about specific genes is GeneCards.org.  Just type your gene name into the “Explore a Gene” search box and appreciate the power of the Internet!  NCBI PubMed contains a huge database of scientific papers – search for your gene and see what articles are out there.

You can use all of this information to edit the Chromosome Project Template Slides also located in Google Classroom.  If time permits, continue researching the disease/condition you selected.  Your goal is to learn what you can about what the disease/condition is and how it is inherited.

Welcome to research!  Use your time well and challenge yourself to learn new things!

Weather: Chapter 10 Quiz

In preparation for the Chapter 10 Quiz, students worked together as a class to answer the Chapter 10 practice questions at the end of the chapter.  Pictures of their work written on the whiteboards are shown below:

Students may use one page of notes for the quiz.  After the quiz, students will prepare for tomorrow’s activity (they will have a substitute teacher) by writing a procedure for how to measure the interior volume of our classroom, taking into account the volume occupied by fixed structures.