Central Dogma: Case Study of Cystic Fibrosis

Because of the short week, today was a full schedule Friday.  We took advantage of the longer class period by learning about the stop codon, focusing on cystic fibrosis as a model disease caused by a genetic mutation which introduces a premature stop codon in about 10% of people with CF.  After watching an inspiring music video about a 15-year-old young man with CF, students learned more about the disease and genetic mutations in general.  We finished with a game where students practiced converting amino acid sequences to RNA and then replacing individual bases to create stop codons.  The lesson plan, along with example sequences from the game can be found here.